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Job Description
Our client, based in Cambridgeshire, is looking for a LC-MS/MS expert to strengthen their Bioanalysis group in the role of Senior Scientist. You will be able to establish given client methods in the laboratories and develop new methods for novel compounds to tight deadlines. Additionally, you will see the method through validation stage and on to its use in pre-clinical or clinical studies.
Key area of work within this area are:
1. Development and validation of qualitative / quantitative assays for screening biological samples for drugs, peptides and proteins
* Characterisation of antibodies
* Enzyme immunoassay, Radioimmunoassay, DELFIA, Gyrolab
* Multiplexing technology
* PK analysis of therapeutic biologics
* Immunogenicity of biologics
* Biomarker quantification
* Mass spectrometry e.g. peptide mapping, protein ID and quantification
* Automation of assays, integration into LIMS
2. Automated screening of samples for safety testing and clinical markers
* Clinical Biochemistry
* Haematology and Coagulation
* Immunology / Virology
3. Protein Chemistry
* Immunoaffinity chromatography
* Electrophoresis
* Enzyme activity assays
JOB SPECIFICATION
Essential Requirements
* Degree in a chemistry or analytical science, or relevant experience
* Good understanding of mass spectrometry, uplc and bioanalytical extraction techniques
* Conscientious and meticulous in laboratory work
* Proven track record of carrying out method development, validation, sample analysis and trouble-shooting problematic methods
* Good communicator with confidence and ability to talk directly to external customers
* Good written communication skills
* Ability to work with minimum supervision and as part of a team
* Good time management skills and ability to work to tight deadlines
* Highly motivated
* Willing to get involved with new ideas and initiatives
* Supervision and training of junior staff
Desirable
* Experience of managing bioanalysis projects in a customer focused organisation
* Experience in a GLP/GCP accredited laboratory
* Previous Study Director and/or supervisory experience in a regulated environment
* Experience with AB Sciex mass spectrometers and software
* Familiarity with Watson LIMS
Key Responsibilities
* Method development, validation and trouble-shooting problematic methods
* Analysis of pre-clinical and clinical samples using LC-MS/MS based methods
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